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CAS No.: 84-26-4

吴茱萸次碱 Catalog No. CSN16640

Synonyms: 吴茱萸次碱;Rutecarpine

Rutaecarpine, a COX-2 inhibitor, is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs.

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400-920-2911

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生物活性

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技术信息

生物活性

描述Rutaecarpine inhibited COX-2 and COX-1 dependent phases of PGD2 generation in BMMC in a concentration-dependent manner with an IC50 of 0.28 microM and 8.7 microM, respectively. It inhibited COX-2-dependent conversion of exogenous arachidonic acid to PGE2 in a dose-dependent manner by the COX-2-transfected HEK293 cells. However, rutaecarpine inhibited neither PLA2 and COX-1 activity nor COX-2 protein and mRNA expression up to the concentration of 30 microM in BMMC, indicating that rutaecarpine directly inhibited COX-2 activity. Furthermore, rutaecarpine showed in vivo anti-inflammatory activity on rat lambda-carrageenan induced paw edema by intraperitoneal administration^[3]. Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems^[4]. Rutaecarpine significantly decreased the number of antibody-forming cells and caused weight decrease in spleen in a dose-dependent manner, when mice were administered with rutaecarpine at 10 mg/kg, 20 mg/kg, 40 mg/kg or 80 mg/kg once intravenously. A single bolus intravenous injection of rutaecarpine from 20 mg/kg might cause immunosuppressive effects, and that rutaecarpine-induced immunosuppression might be mediated, at least in part, through the inhibition of cytokine production and cell cycle arrest in G(0)+G(1) phase, and caused possibly by mechanisms associated with metabolic activation^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4805 mL
- 17.4025 mL
- 34.8050 mL
- 5 mM
- 0.6961 mL
- 3.4805 mL
- 6.9610 mL
- 10 mM
- 0.3480 mL
- 1.7402 mL
- 3.4805 mL

技术信息

CAS号

84-26-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H13N3O

运输

蓝冰

分子量

287.32

别名

吴茱萸次碱;Rutecarpine

溶解度

DMSO	24.0 mg/mL (83.5 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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